Soluble ST2 Levels Are Associated with Bleeding in Patients with Severe Leptospirosis
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Soluble ST2 Levels Are Associated with Bleeding in Patients with Severe Leptospirosis
BACKGROUND Severe leptospirosis features bleeding and multi-organ failure, leading to shock and death. Currently it is assumed that both exaggerated inflammation and immune suppression contribute to mortality in sepsis. Indeed, several proinflammatory cytokines are reported to be induced during leptospirosis. Toll-like receptors, which play an important role in the initiation of an innate immun...
متن کاملSerum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy
Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 co...
متن کاملIncreased Levels of Soluble ST2 in Patients with Active Newly Diagnosed ANCA-Associated Vasculitis
OBJECTIVE ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV). METHODS 139 AAV patients and 62 controls were s...
متن کاملHigh serum nitric oxide levels in patients with severe leptospirosis.
Leptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gram-negative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2009
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000453